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Nrf2 is inactive in the cytosol, where it is bound to Keap1, and in the presence of oxidative stress or electrophiles, it separates from Keap1 and translocates into the cell nucleus [20]

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Interstitial lung disease has been associated with cobalt in susceptible individuals (Sprince et al., 1988), although in a study involving the manufacture of permanent magnets (Deng et al., 1991) abnormalities in pulmonary function and respiratory symptoms were no higher than those of a reference population, except for 4 subjects out of 362, who showed diffuse patches consistent with pneumoconiosis